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Triptolide

商品编号: TL0215
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详细介绍

l  基本信息

产品名称

雷公藤甲素(Triptolide)

一般描述

Triptolide(雷公藤甲素)  is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese  herb Tripterygium wilfordii.

别 称

Triptolid; PG490;NSC 163062

纯 度

≥98%  (HPLC)

CAS NO.

38748-32-2

分子式

C20H24O6

分子量

360.40

适用范围

生物试剂,适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25)

DMSO

≥30mg/mL

乙醇

Insoluble

Insoluble

l  生物学信息

生物活性/药理作用

Triptolide is a diterpene triepoxide, the  principal active ingredient in extracts from the Chinese herb Tripterygium  wilfordii hook (TwHF). It is a potent immunosuppressant and  anti-inflammatory. Triptolide has been shown to inhibit the  of  IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-κB  mediated tranion activation. It synergizes with cyclosporin A in  promoting graft survival in animal models and in suppression of graft versus  host disease in allogeneic bone marrow transplants. In addition, it induces  apoptosis in tumor cells and potentiates tumor necrosis factor (TNFα)  induction of apoptosis in part through the suppression of c-IAP2 and c-IAP1  induction.

应 用

1. Antineoplastic Agents, Alkylating

2. Immunosuppressive Agents

3. Antispermatogenic Agents

4. Triptolide has been used as a NF-κB  inhibitor to study the inhibition of cell invasion and angiogenesis in human  thyroid cancer cells.

5. Triptolide has also been used to study  its apoptotic effects in anaplastic thyroid cancer cells.

l  包装与存储

包 装

5mg;  25mg

存储温度

-20

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov