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Salinomycin

商品编号: TL0288
图示 货号 库存 价格(¥) 数量

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质量文档

详细介绍

l  基本信息

产品名称

盐霉素(Salinomycin)

一般描述

Salinomycin(盐霉素),   traditionally used as an anti-coccidial drug, has recently been shown to   possess anti-cancer and anti-cancer stem cell (CSC) effects.

别 称

(2R)-2-[(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-[(3S,5S,7R,9S,10S,12R,15R)-3-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.5^{7}.3^{5}]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic   acid; Coxistac;Bio-cox

纯 度

≥97%(HNMR)

CAS NO.

53003-10-4

分子式

C42H70O11

分子量

751.011

适用范围

生物试剂,适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25℃)

DMSO

≥50mg/mL

乙醇

≥50mg/mL

Insoluble

l  生物学信息

生物活性/药理作用

Salinomycin produced by Streptomyces albus is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as   breast, lung, gastric cancer, leukemia and osteosarcoma. Salinomycin inhibits   multidrug resistance protein 1 and induces apoptosis by the generation of reactive oxygen species that cause DNA damage and inactivation of Stat3. Use of salinomycin as antibiotic results in lowered spermatozoa count and   motility and decreased steroidogenesis in mice.

应 用

1. Anti-Bacterial Agents

2. Coccidiostats

3. Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples.

4. Salinomycin was used to screen out CD44+CD24- mesenchymal-like subpopulation within breast carcinomas.

l  包装与存储

包 装

10mg;   50mg; 250mg

存储温度

-20

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov