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Panobinostat

商品编号:TL0162
图示 货号 库存 价格 数量

质量文档

详细介绍

l  基本信息

产品名称

帕比司他(Panobinostat)

一般描述

Panobinostat(帕比司他), a cinnamic hydroxamic acid analogue, is a novel broad-spectrum inhibitor of HDAC with potential antineoplastic activity.

别 称

(E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide; LBH-589; LBH589; Farydak;

纯 度

≥98% (HPLC)

CAS NO.

404950-80-7

分子式

C21H23N3O2

分子量

349.434

适用范围

生物试剂,适用于细胞培养等

l  理化信息

外 观

白色或类白色固体

溶解性(25)

DMSO

≥50mg/mL

乙醇

Insoluble

Insoluble

l  生物学信息

生物活性/药理作用

Panobinostat is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. HDAC is an enzyme that deacetylates chromatin histone proteins.

应 用

1. Antineoplastic Agents

2. Histone Deacetylase Inhibitors

l  包装与存储

包 装

5mg; 25mg; 100mg

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov