产品名称

Prostaglandin F Synthase human

别 称

17-beta-hydroxysteroid dehydrogenase type 5, AKR1C3, aldo-keto reductase family 1 member C3, indanol dehydrogenase

含 量

recombinant, expressed in E. coli, ≥90%  (SDS-PAGE)

CAS  NO.

55976-95-9

分子量

mol wt ~37 kDa

适用范围

生物试剂

l  生物学信息

生物活性/药理作用

PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17β-estradiol, prostaglandin H2 to PGF2α, and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways.

应 用

Prostaglandin F synthase (PGF synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. Prostaglandin F synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. PGF synthase is also used to study kidney and renal cell carcinoma.

有效单位定义

One unit is defined as the amount of enzyme required to produce 1 μmol of NADP per minute at 37°C in 50 mM KPO4 pH 7.2 containing 250 μM NADPH and 25 μM 9,10-phenanthrenequinone

l  包装与存储

存储温度

−70°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov