产品名称

Pyranose Oxidase from Coriolus sp.

别 称

Pyranose: Oxygen 2-Oxidoreductase

含 量

≥2.7 units/mg solid, recombinant, expressed in E. coli

CAS  NO.

37250-80-9

MDL  number

MFCD03458318

适用范围

生物试剂

l  理化信息

外 观

淡黄色至深黄色粉末

l  生物学信息

生物活性/药理作用

Pyranose oxidase (P2O) catalyzes the oxidation of aldopyranoses at position C-2 to yield the corresponding 2-ketoaldoses. P2O is a homotetrameric protein that contains covalently bound flavin adenine dinucleotide (FAD). The in vivo substrates of P2O are thought to be D-glucose, D-galactose, and D-xylose. They are oxidized to 2-keto-D-glucose (D-arabino-hexos-2-ulose, 2-dehydro-D-glucose), 2-keto-D-galactose (D-lyxo-hexos-2-ulose, 2-dehydro-D-galactose), and  2-keto-D-xylose (D-threopentos-2-ulose, 2-dehydro-D-xylose), respectively.  Pyranose oxidase has significant activity with carbohydrates such as, L-sorbose, D-glucono-1,5-lactone, and D-allose. When pyranose oxidase catalyzes the oxidation of aldopyranoses, electrons are transferred to molecular oxygen which results in the formation of hydrogen peroxide.

应 用

Pyranose oxidase (P20) is used for the determination of D-glucose and 1,5-anhydroglucitol in clinical analysis. It is used to study the biotransformations of carbohydrates and is used as an important marker for glycemic control in diabetes patients.

有效单位定义

One unit produces 1.0 μmol of hydrogen peroxide per minute at 37 °C, pH 7.0.

l  包装与存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov