产品名称

Chloroperoxidase from Caldariomyces fumago

别 称

Chloride Peroxidase, Chloride:hydrogen-peroxide oxidoreductase

含 量

1,000-2,000 units/mg protein (E1%/280)

CAS  NO.

9055-20-3

MDL  number

MFCD00130774

适用范围

生物试剂

l  理化信息

外 观

缓冲水悬浮液

物理形态

Purified suspension in 0.1 M sodium phosphate solution, pH approx. 4.5

l  生物学信息

生物活性/药理作用

Chloroperoxidase (CPO) is a 42,000 Da extracellular heme glycoenzyme containing ferriprotoporphyrin IX as the prosthetic group. CPO is secreted from fungus and exhibits a broad spectrum of chemical reactivities. It is a peroxide-dependent chlorinating enzyme. It also catalyzes peroxidase-, catalase- and cytochrome P450-type reactions of dehydrogenation, H²O² decomposition and oxygen insertion, respectively. The enzyme has magnetic and spectroscopic properties similar to that of cyctochrome P-450. CPO from the fungus Caldariomyces fumago has the capacity to chlorinate aromatic hydrocarbons, including polycyclic aromatic hydrocarbons (PAHs).

应 用

A useful alternative to lactoperoxidase for ₁₃₁I ion labeling studies, for bromination of proteins, and for ₃₆Cl labeling of macromolecules in long-term isolation procedures.

有效单位定义

One unit will catalyze the conversion of 1.0 μmole of monochlorodimedon to dichlorodimedon per min at pH 2.75 at 25 °C in the presence of potassium chloride and H²O².

l  存储

存储温度

2-8°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov