产品名称

Myeloperoxidase from human leukocytes

一般描述

Myeloperoxidase (MPO) is encoded by the gene mapped to human chromosome 17q22-24.The encoded protein is a leukocyte-derived enzyme and is an integral constituent of the innate immune response. MPO belongs to the heme peroxidase superfamily. MPO is a heme protein containing iron and is highly expressed in leukocytes, neutrophils, monocytes and some subtypes of tissue macrophages.

别 称

MPO, Peroxidase, myelo

含 量

≥50 units/mg protein

CAS  NO.

9003-99-0

MDL  number

MFCD00131641

适用范围

生物试剂

l  理化信息

外 观

浅绿色冻干粉末

溶解性(25°C)

H²O: soluble aqueous buffers such as 50 mM sodium acetate:soluble (Freezing of the enzyme in solution may result in a substantial loss of activity.)

物理形态

Lyophilized from 50 mM sodium acetate  buffer, pH 6.0, 0.1 M sodium chloride

l  生物学信息

生物活性/药理作用

Myeloperoxidase (MPO) has a crucial role to play in destruction of various microorganisms and foreign cells, such as bacteria, fungi, viruses, red cells and malignant and nonmalignant nucleated cells.MPO catalyzes the production of number of reactive oxidant species (ROS) that influence tissue damage during inflammation. MPO and its downstream inflammatory pathways function as a potent therapeutic target for prophylaxis of atherosclerotic cardiovascular disease.MPO catalyze the synthesis of polychlorinated dibenzo(p)dioxins and furans (PCDD/F) from precursor such as chlorophenols in presence of hydrogen peroxide (H²O²).

应 用

Myeloperoxidase (MPO) from human leukocytes has been used in MPO assay.

有效单位定义

One unit of myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of ¹/₄  micromole of tetraguaiacol per minute at pH 7.0 and 25 °C

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov