产品名称

4-Hydroxyphenylpyruvate Dioxygenase from Streptomyces avermitilis

一般描述

4-Hydroxyphenylpyruvate Dioxygenase  (4-HPPD) is a key enzyme in the catabolism of tyrosine and phenylalanine. 4-HPPD catalyzes the synthesis of homogenistate (2,5-dihydroxyphenylacetate)  from ρ-hydroxyphenylpyruvate and molecular oxygen. 4-HPPD also catalyzes the conversion of α-ketoisocaproate to Β-hydroxyisovalerate. 4-HPPD requires Fe₂₊ as an essential cofactor. Rat 4-HPPD has a minimum of 80% homology with human 4-HPPD. Rat 4-HPPD is expressed abundantly in hepatocytes. It is also  expressed in kidney, particularly in epithelial cells of the proximal tubules and the distant tubules. 4-HPPD has been identified as a potential biomarker of drug-induced liver injury in rat studies.

别 称

4-HPPD, p-HPPD, a-ketoisocaproate

含 量

recombinant, expressed in E. coli, ≥ 1mg/mL(Concentration), ≥ 5UN/mg(Specific Activity)

适用范围

生物试剂

l  生物学信息

有效单位定义

One unit will oxidize 1 μmole of molecular oxygen per minute at pH 7.0, 25 °C, in the presence of 4-hydroxyphenylpyruvate.

l  包装与存储

存储温度

The recommended long-term storage temperature for the product is –70 °C.

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov