产品名称

Glutathione Reductase human

别 称

GR, Glutathione-disulfide reductase, NADPH:oxidized glutathione oxidoreductase

含 量

≥10 units/mg protein, recombinant, expressed in E. coli

CAS  NO.

9001-48-3

MDL  number

MFCD00131196

适用范围

生物试剂

l  理化信息

外 观

淡黄色至黄色缓冲水溶液

物理形态

Solution containing 25 mM Tris-HCl, pH 7.4, 1 mM EDTA, and 50% (v/v) glycerol.

l  生物学信息

生物活性/药理作用

Glutathione reductase enzyme is a  homodimeric enzyme containing 1 FAD molecule and 1 NADPH binding domain per subunit. Both human GR (hGR) and Plasmodium falciparum GR (PfGR) are essential for the survival of the malaria parasite within the human erythrocyte. Thus, this enzyme may be used for studies of candidate anti-malaria reagents.Glutathione reductase is a ubiquitous flavoenzyme involved in the protection from cell stress. Glutathione reductase catalyzes the reduction of oxidized glutathione (GSSG) to glutathione (GSH). It is essential for the glutathione redox cycle that maintains adequate levels of reduced cellular GSH, which serves as an antioxidant reacting with free radicals and organic peroxides. Glutathione is also an electron donor for  glutathione peroxidases and a substrate for glutathione S-transferases contributing to the detoxification and elimination of toxic electrophilic bolites and xenobiotics.

应 用

Human glutathione reductase has been used in:

•  glutathione reductase activity assay

•  oxidative stress analysis

•  redox assays

有效单位定义

1 unit will reduce 1.0 μmole of DTNB to TNB per minute at 25°C at pH 7.5.

l  包装与存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov