产品名称

Cyclin-Dependent Kinase 5 human

含 量

50-100 units/μg protein; recombinant, expressed in E. coli BL21

MDL  number

MFCD06201997

适用范围

生物试剂

l  理化信息

物理形态

Supplied as a solution in PBS pH 7.4, 1mM  EDTA, 1mM DTT and 1mg/ml BSA

l  生物学信息

生物活性/药理作用

CDK5 is highly expressed in the nervous system where it phosphorylates a multitude of substrates. CDK5 plays an important role in many processes such as: apoptosis, phototransduction, dopamine and glutamate signalling, neurite outgrowth, neurone migration, induction of acetylcholine receptors, golgi membrane traffic and insulin exocytosis. It has also been implicated in the pathogenesis of amyotrophic lateral sclerosis . It is activated by p35 and p39, and their proteolytic cleavage products, p25 and p29.

应 用

Human cyclin-dependent kinase 5 has been used in a study to determine its 3’ untranslated region subunit 1 contains regulatory elements that affect tran stability.

有效单位定义

One unit will phosphorylate 1.0 picomole of the peptide substrate histone H19-18 per minute at 30°C at pH 7.4.

l  存储

存储温度

-70°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov