产品名称

Ribonuclease A, with scrambled disulfide bonds from bovine pancreas

含 量

PDI substrate; protein ≥50% by UV; ≤2 Kunitz units/mg protein

MDL  number

MFCD00132181

适用范围

生物试剂

l  理化信息

外 观

白色至淡黄色粉末

溶解性(25°C)

Colorless to Light Yellow to Light Beige ; Clear to Slightly Hazy; 1mg/mL, 0.01M HOAc

l  生物学信息

生物活性/药理作用

RNA substrates lie in the cleft of RNase A and are cleaved by histidine 12 and histidine 119, via a 2′-3′ cyclic phosphate intermediate. The intermediate is then stabilized by nearby lysines such as Lys7, Lys41 and Lys66.

应 用

Ribonuclease A (RNase A) is a pancreatic ribonuclease that cleaves single-stranded RNA. RNase A, and several homologs, may be useful as cancer therapeutics due to their cytotoxic effects on cancer cells. Rnase A is useful in the elucidation of protein structure and absorbance. RNase A has been used as a model system in the study of computer-aided drug design . Product R2638 has scrambled disulfide bonds and is from bovine pancreas.

样品准备说明

Prepared from Type I-A RNase by the method of Hillson, D.A., et al., Meth. Enzymol., 107, 281 (1984).

l  包装与存储

存储温度

−20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov