产品名称

Butyrylcholinesterase from human serum

别 称

Acylcholine acyl-hydrolase, Choline esterase, butyryl, Pseudocholinesterase

含 量

≥50 units/mg protein; vial of ≥4 units

Starting material individually donor tested and found negative for HIV I & II antibodies, Hepatitis B surfaceantigen, and Hepatitis C antibodies.

CAS  NO.

9001-08-5

MDL  number

MFCD00081455

适用范围

生物试剂

l  生物学信息

生物活性/药理作用

Butyrylcholinesterase (BChE) is a serine hydrolase that shares substantial structural similarities with acetylcholinesterase (AchE) but has different substrate and inhibitor specificities. BChE is found in the serum, hemopoietic cells, liver, lung, heart and the central nervous system of vertebrates.

应 用

Butyrylcholinesterase (BChE) may be used to hydrolyze large esters of choline such as butyrylcholine and benzoylcholine. Selective inhibition of BChE activity can be used in the detection of organophosphates. BchE may be used to treat organophosphate toxicity. It may be a useful tool in Alzheimer’s research. BchE, from Sigma, has been used to determine butyrylcholinesterase inhibition by various test compounds.

有效单位定义

One unit will hydrolyze 1.0μmole of butyrylcholine to choline and butyrate per min at pH8.0 at 37°C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine.

l  存储

存储温度

2-8°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov