Phosphodiesterase 5A1 human
商品编号:
S0389
备注:
国外库存,货期2-4周,具体详情请联系销售人员。
详细介绍
l 基本信息 |
产品名称 | Phosphodiesterase 5A1 human |
别 称 | 3′,5′-cyclic-GMP phosphodiesterase, PDE 5A1 |
含 量 | recombinant, expressed in Sf9 cells; ≥0.1mg protein/ml (Bradford) ; ≥2,000 unit/μg protein |
适用范围 | 生物试剂 |
l 理化信息 |
物理形态 | Supplied as a solution in 20% glycerol containing 40 mM Tris-HCl, pH8.0, 110mM NaCl, 2.2mM KCl, 0.04% TWEEN-20
and 3mM DTT |
l 生物学信息 |
生物活性/药理作用 | PDE5 regulates vascular smooth muscle contraction and is involved in NO-cGMP signaling in platelets to control aggregation. PDE5 may also be involved in the regulation of cGMP signaling in the brain and may modulate pressure-induced cardiac hypertrophy and fibrosis. |
应 用 | Phosphodiesterase (PDE) is an enzyme that is used to breaks phosphodiester bonds. PDE5 is a molecular target for the treatment of erectile dysfunction and pulmonary hypertension. PDE5 is used to find novel PDE5 inhibitors . |
有效单位定义 | One unit will convert 1.0 picomole of
3′,5′-cGMP to 5′-GMP per minute at pH7.4 at 37°C. |
l 存储 |
存储温度 | −70°C |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |