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Phosphodiesterase 5A1 human

商品编号: S0389
图示 货号 库存 价格(¥) 数量

备注:

国外库存,货期2-4周,具体详情请联系销售人员。

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详细介绍

l  基本信息

产品名称

Phosphodiesterase 5A1 human

别 称

3′,5′-cyclic-GMP phosphodiesterase, PDE 5A1

含 量

recombinant, expressed in Sf9 cells; ≥0.1mg protein/ml (Bradford) ; ≥2,000 unit/μg protein

适用范围

生物试剂

l  理化信息

物理形态

Supplied as a solution in 20% glycerol containing 40 mM Tris-HCl, pH8.0, 110mM NaCl, 2.2mM KCl, 0.04% TWEEN-20  and 3mM DTT

l  生物学信息

生物活性/药理作用

PDE5 regulates vascular smooth muscle contraction and is involved in NO-cGMP signaling in platelets to control aggregation. PDE5 may also be involved in the regulation of cGMP signaling in the brain and may modulate pressure-induced cardiac hypertrophy and fibrosis.

应 用

Phosphodiesterase (PDE) is an enzyme that is used to breaks phosphodiester bonds. PDE5 is a molecular target for the treatment of erectile dysfunction and pulmonary hypertension. PDE5 is used to find novel PDE5 inhibitors .

有效单位定义

One unit will convert 1.0 picomole of  3′,5′-cGMP to 5′-GMP per minute at pH7.4 at 37°C.

l  存储

存储温度

−70°C

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov