产品名称

Leukotriene A⁴ Hydrolase human

别 称

LTA-4 hydrolase, LTA4, LTA₄H

含 量

recombinant, expressed in E. coli; ≥90%(SDS-PAGE)

CAS  NO.

90119-07-6

分子量

mol wt ~69 kDa

MDL  number

MFCD08460576

适用范围

生物试剂

l  理化信息

物理形态

Supplied as a solution in 100mM Tris, pH8.0, containing 20% glycerol and 100mM potassium chloride.

l  生物学信息

生物活性/药理作用

Leukotriene A⁴ Hydrolase human (LTA⁴H) is a bifunctional zinc lloenzyme that converts LTA4  into Leukotriene B4, and also demonstrates aminopeptidase activity. Leukotriene B4 is a lipid chemoattractant that plays critical roles in inflammaton, immune responses, host defenses against infections, and lipid homeostasis. Inhibition of LTA4H in a mouse model decreases LTB4 in the airways and attenuates airway inflammation and airway hyperreactivity through modulation of T cell and dendritic cell function.

应 用

Leukotriene A⁴ Hydrolase human (LTA⁴H) is a drug target for anti-inflammation, and for cancer prevention and therapy. It is also suitable for screening inhibitors of Leukotriene B4 synthesis. LTA⁴H is used to study allergic asthma and airway hyperresponsiveness.

l  存储

存储温度

−70°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov