产品名称

Protein C from human plasma

别 称

Activated Protein C

含 量

Activated, ≥90%(SDS-PAGE)

CAS  NO.

42617-41-4

分子量

heavy chain mol wt 41kDa; light chain mol  wt 21 kDa

MDL  number

MFCD00165567

适用范围

生物试剂

l  理化信息

外 观

白色冻干粉

物理形态

Lyophilized powder from 20mM Tris-HCl, pH7.4, containing 0.1M NaCl

溶解性(25°C)

H²O: 1mg/mL

l  生物学信息

生物活性/药理作用

In addition, activated protein C has been shown to inhibit TNF-α induced of the inflammatory proteins VCAM, ICAM-I, and Ilk-8 in endothelial cells.

Protein C is a plasma, vitamin κ-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa. The Protein C anticoagulant pathway is triggered when thrombin binds to the endothelial cell proteoglycan, thrombomodulin. This complex, which cannot clot blood, is a potent activator of the protein C zymogen. Activation involves the release of a dodecapeptide from the N-terminal domain of the heavy chain. The activated Protein C (APC) then binds to protein S on cell surfaces and inactivates the coagulation factors Va and VIIIa by proteolysis.  APC has also been shown to bind to receptors on the endothelium of large blood vessels.

Protein C is a plasma, vitamin κ-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa.

样品准备说明

Lyophilized powder from 20mM Tris-HCl, pH7.4, containing 0.1M NaCl

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov