产品名称

Plasmin from human plasma

一般描述

Plasmin functions as a key enzyme of the fibrinolytic cascade, and is also important in inflammation processes.

别 称

Fibrinolysin

含 量

≥2.0units/mg protein

CAS  NO.

9001-90-5

MDL  number

MFCD00131921

适用范围

生物试剂

l  理化信息

外 观

冻干粉

物理形态

Lyophilized powder containing sodium phosphate, mannitol, and NaCl.

l  生物学信息

生物活性/药理作用

Plasmin exhibits preferential cleavage at the carboxyl side of lysine and arginine residues with higher selectivity than trypsin. Converts polymerized fibrin into soluble products.

pH Optimum: 8.5

pH 7.5: ~40% of maximal activity, pH9.5:~50% of maximal activity

Temperature Optimum: 37°C with rapid inactivation at 56°C

Plasmin is inhibited by α 2-antiplasmin which binds to plasmin blocking its interaction with fibrin. Plasmin digests the N-terminal region of the cytoplasmic protein αsynuclein preventing its uptake by surrounding cells.

应 用

A complex between plasmin and an inhibitor has been isolated in a study via affinity chromatography from urokinase-activated human plasma. It has also been used in a study to investigate activation of human epithelial sodium channel (ENaC) by plasmin and chymotrypsin.

样品准备说明

Lyophilized powder containing sodium phosphate,mannitol, and NaCl.

有效单位定义

One unit will produce one μmole of p-Nitroanilide from D-Val-Leu-Lys-p-Nitroanilide per minute at pH7.5 at 37°C.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov