产品名称

Cathepsin B from human liver

别 称

Cathepsin B1

含 量

≥1,500units/mg protein (E1%/280)

CAS  NO.

9047-22-7

MDL  number

MFCD00130748

适用范围

生物试剂

l  理化信息

外 观

缓冲水溶液

物理形态

Solution in 50mM sodium acetate, pH5.0, with 1mM EDTA.

l  生物学信息

生物活性/药理作用

Cathepsin B has been found to cleave procaspase 1 and procaspase 11 and to induce apoptosis in digitonin-permeabilized cells. Translocation of cathepsin B from the cytoplasm to the nucleus contributes to bile salt induced apoptosis of rat hepatocytes. Levels of cathepsin B in PC12 cells significantly decrease 12 to 24 hours after apoptosis is induced.

样品准备说明

Solution in 50mM sodium acetate, pH5.0, with 1mM EDTA.

有效单位定义

One unit will liberate 1 nanomole of 7-amino-4-methylcoumarin from Z-Arg-Arg 7-amido-4-methylcoumarin per min at pH6.0 at 40°C.

l  存储

存储温度

−70°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov