产品名称

Calpain 1 human

别 称

Calcium-activated neutral protease 1

含 量

≥95%(SDS-PAGE)

MDL  number

MFCD00217575

适用范围

生物试剂

l  理化信息

外 观

甘油水溶液

物理形态

Solution in 20mM Imidazole-HCl, 5mM β-Mercaptoethanol,1mM EDTA,1mM EGTA, and 30% glycerol.

l  生物学信息

生物活性/药理作用

Cytosolic protease with involvement in cytoskeletal remodeling, autophagy, and apoptosis as an upstream regulator.

Caplain 1 is a neutral calcium-dependent cysteine protease containing the EF-hand motif. The protease consists of two subunits; the larger subunit has four domains that are homologous with papain and calmodulin. The smaller subunit has one domain that shares homology with calmodulin. It is activated by micromolar levels of calcium and hence, it is also called as micro-calpain. Its activation leads to cellular protein degradation, neuronal cell degeneration, and autoimmune demyelinating diseases such as multiple sclerosis.

应 用

Human calpain 1 has been used in a study to assess how the crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition. Human calpain 1 has also been used in a study to investigate the synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors.

样品准备说明

Solution in 20mM Imidazole-HCl, 5mM β-Mercaptoethanol,1mM EDTA,1mM EGTA, and 30% glycerol.

l  存储

存储温度

−70°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov