产品名称

Cathepsin D from human liver

含 量

≥250units/mg protein (E1%/280)

CAS  NO.

9025-26-7

分子量

mol wt ~45 kDa

MDL  number

MFCD00130749

适用范围

生物试剂

l  理化信息

外 观

白色冻干粉

物理形态

Powder containing sodium phosphate buffer salt.

l  生物学信息

生物活性/药理作用

Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer stasis and Alzheimer’s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human  foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.

样品准备说明

Powder containing sodium phosphate buffer salt.

有效单位定义

One unit will produce an increase in A²⁸⁰of 1.0 in 30 min at pH3.3 at 37°C measured as TCA-soluble products using acid-denatured hemoglobin as substrate (1cm light path).

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov