产品名称

Acylase I from porcine kidney

别 称

Aminoacylase, N-Acylamino acid amidohydrolase

含 量

Grade II, 500-1,500units/mg protein

CAS  NO.

9012-37-7

MDL  number

MFCD00081285

适用范围

生物试剂

l  理化信息

外 观

类白色至棕色无盐冻干粉

l  生物学信息

生物活性/药理作用

Acylase I is a zinc lloprotein that catalyzes the kinetic resolution of unnatural and rarely occurring α-amino acids. Its enantioselectivity for the hydrolysis of N-acyl L-α-amino acids is nearly absolute, yet it accepts substrates having a wide range of structure and functionality. Acylase I catalyzes the deacetylation of N-acetyl-L-cysteine and S-alkyl-N-acetyl-L-cysteines. n-Butylmalonic acid is an inhibitor of acylase I. S-alkyl-N-acetyl-L-cysteines with short (C0-C3) and unbranched S-alkyl substituents have been found to be good acylase I substrates.

应 用

Acylase I from porcine kidney has been used to study the acylase I-catalyzed deacetylation of various. S-alkyl-N-acetyl-L-cysteines and their carbon and oxygen analogues. Acylase I may be useful to catalyze N-acetyl amino acids to enantiomerically pure L-amino acids.

有效单位定义

One unit will hydrolyze 1.0μmole of N-acetyl-L-methionine per hr at pH7.0 at 25°C.

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov