产品名称

Carbonic Anhydrase Isozyme II from bovine erythrocytes

别 称

Carbonate Dehydratase, Carbonate Hydrolyase, Carbonic Anhydrase II

含 量

≥3,000W-A units/mg protein

CAS  NO.

9001-03-0

MDL  number

MFCD00081467

适用范围

生物试剂

l  理化信息

外 观

白色冻干粉

l  生物学信息

生物活性/药理作用

Carbonic anhydrase is a zinc lloenzyme that has a molecular weight of approximately 30,000 Da. The enzyme catalyzes the hydration of carbon dioxide to carbonic acid. It is involved in many physiological and pathological processes such as pH and CO² homeostasis, transport of bicarbonate and CO²,biosynthetic reactions, bone resorption, calcification, and tumorigenicity. Therefore, inhibitors that block this enzyme can have therapeutic implications in glaucoma, epilepsy and Parkinson′s disease.

应 用

Carbonic anhydrase from sigma has been used  for the analysis of thermodynamic stability of the enzyme by measuring the  binding affinity and stoichiometry. The enzyme has also been used to generate CD4₊ T cell lines specific for carbonic anhydrase during the study of autoimmune pancreatitis in rat.

有效单位定义

One Wilbur-Anderson (W-A) unit will cause the pH of a 0.02M Trizma buffer to drop from 8.3 to 6.3 per min at 0°C.  (One W-A unit is essentially equivalent to one Roughton-Booth unit.)

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov