产品名称

Carbonic Anhydrase I from human erythrocytes

别 称

Carbonate Dehydratase, Carbonate Hydrolyase, Carbonic Anhydrase Isozyme I

含 量

Protein(Biuret): ≥80%; 100-500W-A units/mg protein

CAS  NO.

9001-03-0

MDL  number

MFCD00081467

适用范围

生物试剂

l  理化信息

外 观

白色粉末

l  生物学信息

生物活性/药理作用

Carbonic anhydrase is a zinc lloenzyme that has a molecular weight of approximately 30,000Da. The enzyme catalyzes the hydration of carbon dioxide to carbonic acid. It is involved in vital processes such as pH and CO² homeostasis, transport of bicarbonate and CO², biosynthetic reactions, bone resorption, calcification, and tumorigenicity. Therefore, this enzyme is an important target for inhibitors with clinical applications in various pathologies such as glaucoma, epilepsy and Parkinson’s disease.

应 用

Carbonic anhydrase from human erythrocytes (HCA) has been used to study the molten-globule state of carbonic anhydrase (CA). Chaperone-like α-crystallin binds to this state of the enzyme and prevents its aggregation.The enzyme from sigma has been used for the analysis of thermodynamic stability of the enzyme.Furthermore, its clinical significance has been evaluated in human non-small cell lung cancer.

有效单位定义

One Wilbur-Anderson (W-A) unit will cause the pH of a 0.02M Trizma buffer to drop from 8.3 to 6.3 per min at 0°C. (One W-A unit is essentially equivalent to one Roughton-Booth unit.)

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov