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Carbonic Anhydrase Isozyme II human

商品编号: S0821
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国外库存,货期2-4周,具体详情请联系销售人员。

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详细介绍

l  基本信息

产品名称

Carbonic Anhydrase Isozyme II human

别 称

Carbonate Dehydratase, Carbonate Hydrolyase

含 量

≥80%, ≥3,000W-A units/mg protein

CAS  NO.

9001-03-0

MDL  number

MFCD00081467

适用范围

生物试剂

l  理化信息

外 观

白色粉末

l  生物学信息

生物活性/药理作用

Carbonic anhydrase is a zinc lloenzyme that catalyzes the hydration of carbon dioxide to carbonic acid. It is involved in pathological and physiological processes such as pH and CO2 homeostasis, transport of bicarbonate and CO2, biosynthetic reactions, bone resorption, calcification, and tumorigenicity. Therefore, this enzyme is an important target for inhibitors that can be used for treating various pathological conditions such as glaucoma, epilepsy and Parkinson’s disease. CAII has a molecular mass of approximately 30 kDa and is primarily present in type II pneumocytes. Due to this unique location it has been speculated that CAII is involved in pulmonary functions such as regulation of fluid secretion and CO2 elimation. Sulfonamides, sulfamates and sulfamides are potent inhibitors of CA.

应 用

Human carbonic anhydrase isozyme II has been used to assess its gene fusion abilities for efficient and recovery of recombinant proteins. Human carbonic anhydrase isozyme II has also been used to investigate a new process for the synthesis of  difluoromethanesulfonamides. Furthermore, CA II from Sigma has been used as a standard to measure the CA activity in lung tissue homogenates. The study analysed the possible relationship between the of carbonic anhydrase and non-small cell lung cancer. The product has also been used with Freund′s complete adjuvant at 1:1 ratio for antibody production. This study evaluated the quantitative and functional alterations of cytosolic CA  isoenzymes in the erythrocytes of glucose-6-phosphate dehydrogenase  (G6PD)-deficient individuals. The enzyme has also been used in the study of natural phenolic inhibitors of CA II.

有效单位定义

One Wilbur-Anderson (W-A) unit will cause the pH of a 0.02M Trizma buffer to drop from 8.3 to 6.3 per min at 0 °C.(One W-A unit is essentially equivalent to one Roughton-Booth unit.)

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov