产品名称

Neuron-specific enolase from human brain

一般描述

Neuron-specific enolase (NSE) is a neuronal form of the glycolytic enzyme enolase, which was first found in extracts of brain tissue.

别 称

2-Phospho-D-glycerate hydro-lyase, Enolase, Neuron-specific from human brain, NSE, Thermolabile antigen A

含 量

≥95%(SDS-PAGE)

MDL  number

MFCD00081785

适用范围

生物试剂

l  理化信息

外 观

缓冲水溶液

l  生物学信息

生物活性/药理作用

Neuron-specific enolase (NSE) is expressed in all neuronal cell types, and its  marks the acquisition of synaptic function. Following acute neuronal injury, NSE levels are increased in neuronal cell bodies. Increased levels of NSE in serum and cerebrospinal fluid have been used as markers for injury and neuronal cell death. Tumors derived from many cell types, including most neuronal and neuroendocrine tumors, express NSE. Neuron-specific enolase promotes survival of neurons and can provide neuroprotective effects by binding to neurons in a calcium-dependent  manner.

应 用

Neuron-specific enolase from human brain has been used in a study to assess human amniotic mesenchymal stem cells in the treatment of focal cerebral ischemia. It has also been used in a study to investigate sinonasal teratocarcinosarcoma with rhabdoid features.

样品准备说明

Solution in 100mM Tris-HCl, 5mM MgSO⁴, 250mM KCl, pH5.0-5.2

有效单位定义

One unit causes the formation of 1.0μmole of phospho(enol)pyruvate per minute at pH6.8 at 25°C

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov