产品名称

Cyclophilin A human

别 称

CyP

含 量

≥95%(SDS-PAGE), recombinant, expressed in  E. coli; ≥0.3mg/mL

CAS  NO.

95076-93-0

MDL  number

MFCD00130885

适用范围

生物试剂

l  理化信息

外 观

缓冲水溶液

l  生物学信息

生物活性/药理作用

Cyclophilins are peptidyl prolyl isomerases that catalyze the cis-trans isomerization of X-Pro peptide bonds. They are highly-conserved cytoplasmic enzymes that accelerate protein folding and facilitate HIV infectivity. Cyclosporin A binds to cyclophilin and inhibits its activity. The cyclosporin A-cyclophilin complex binds to calcineurin and inhibits T-cell activation. The structure of human, recombinant cyclophilin is given by Holzman, et al.

样品准备说明

Composed of amino acids 1-165 plus an N-terminal 20 amino acid His-tag; Solution in 20mM Tris, pH8.0, containing 20mM NaCl,  0.5mM DTT and 10% glycerol

l  存储

存储温度

-20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov