FR 122047 hydrochloride
商品编号：
S0888
备注：
国外库存，货期2-4周，具体详情请联系销售人员。
详细介绍
l 基本信息 |
产品名称 | FR 122047 hydrochloride |
一般描述 | FR 122047 hydrochloride is a cell-permeable trisubstituted thiazole compound that acts as a potent and selective inhibitor of COX-1. |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 130717-51-0 |
分子式 | C23H25N3O3SHCl | 分子量 | 459.99 |
适用范围 | 生物试剂，适用于细胞培养等 |
l 理化信息 |
外 观 | 浅黄色固体 |
l 生物学信息 |
生物活性/药理作用 | A cell-permeable trisubstituted thiazole compound that acts as a potent and selective inhibitor of COX-1 (IC50 = 28 nM and 65 µM for human recombinant COX-1 and COX-2, respectively). Displays ~2,300 fold greater selectivity towards inhibition of COX-1 over COX-2. Reported to be orally active and display analgesic, anti-platelet and anti-inflammatory properties. A potent, cell-permeable, and selective inhibitor of COX-1 (IC50 = 28 nM; human recombinant COX-1). Does not significantly inhibit COX-2 (IC50 = 65 µM, human recombinant COX-2). Reported to be orally active and displays analgesic properties in chemical nociceptive animal models. Also reported to exhibit anti-inflammatory effects and suppress prostaglandin E2 and thromboxane 2 levels in collagen-induced arthritis in rats. Shown to be 100 times more potent than aspirin in inhibiting arachidonic acid- and collagen-induced human and guinea pig platelet aggregation. |
l 存储 |
存储温度 | -20℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
