产品名称

Meloxicam sodium salt hydrate

一般描述

Meloxicam sodium salt hydrate is a non-steroidal anti-inflammatory drug (NSAID).

纯 度

≥98.0%(HPLC)

CAS NO.

71125-39-8 (anhydrous)

分子式

C¹⁴H¹²N³NaO⁴S² · xH²O

分子量

373.38 (anhydrous basis)

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

淡黄色至深黄色固体

溶解性(25℃)

DMSO

≥5mg/mL

l  生物学信息

生物活性/药理作用

Meloxicam, a member of the oxicam family, is a non-steroidal anti-inflammatory drug (NSAID) that shows 300-fold selectivity for cyclooxygenase-2 (COX-2) vs cyclooxygenase-1 (COX-1). Meloxicam has been shown to abolish thymulin-induced increases of cytokines and NGF in the liver of rats. Meloxicam also suppresses tumor growth and may be capable of antagonizing cachexia in vitro.

应用

Meloxicam sodium salt hydrate has been used:

•   as a cyclooxygenase-2 (COX-2) inhibitor in solid Ehrlich tumor

•   as an alternative to diclofenac nonsteroidal anti-inflammatory drugs (NSAID) to treat vultures

•   as a reference standard in liquid chromatography electrospray ionisation mass   spectrometry (LC-ESI/MS)

•   to test its effect on prostaglandin (PGE2) production in lipopolysaccharide (LPS)-induced COX-2 protein in RAW246.7 cells

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov