产品名称

Tenidap

一般描述

Tenidap is an anti-inflammatory and anti-rheumatic with a variety of activities. 

别 称

CP 66248; (3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide

纯 度

≥97.0%(HPLC)

CAS NO.

120210-48-2

分子式

C¹⁴H⁹ClN²O³S

分子量

320.75

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

淡黄色至深黄色固体

溶解性(25℃)

DMSO

Slightly soluble

l  生物学信息

生物活性/药理作用

Tenidap is an anti-inflammatory and anti-rheumatic with a variety of activities. Tenidap preferentially inhibits COX-1 with an IC₅₀ value of 30 nM, and also has some lesser inhibitory activity towards COX-2 and 5-lipoxygenase (IC₅₀ values are 1.2 and > 30 μM for COX-2 and 5-lipoxygenase respectively). Tenidap is also a cytokine modulator, an opener of inward   rectifying hKIR2.3 channels (EC₅₀ = 402 nM) and has been shown to modulate cytoplasmic pH and inhibit anion transport in vitro.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.    https://www.ncbi.nlm.nih.gov