产品名称

1-Aminobenzotriazole

一般描述

1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.

别称

1-Benzotriazolamine, ABT

纯 度

≥98%(TLC)

CAS NO.

1614-12-6

分子式

C⁶H⁶N⁴

分子量

134.14

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

浅黄色至黄褐色固体

溶解性(25℃)

乙醇

≥35mg/mL

l  生物学信息

生物活性/药理作用

Suicide inhibitor of cytochrome P450 and chloroperoxidase.

应用

1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H2O2-induced premature senescence of vascular smooth muscle cells from old rats[2] It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov