产品名称

6-(2-Propargyloxyphenyl)hexanoic acid

一般描述

PPOH is a selective inhibitor of epoxygenation catalyzed by CYP450 isozymes.

别 称

PPOH

纯 度

≥98.0%(HPLC)

CAS NO.

206052-01-9

分子式

C¹⁵H¹⁸O³

分子量

246.3

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

l  生物学信息

生物活性/药理作用

PPOH is a synthetic, acetylenic fatty acid and a selective inhibitor of arachidonate epoxygenation reactions catalyzed by certain microsomal cytochrome P450 (CYP) enzymes. PPOH inhibits the reaction of epoxide formation (IC₅₀ of 90 µM) at arachidonate positions 11 and 12 by CYP4A2 and CYP4A3 isozymes. PPOH does not inhibit the ω-hydroxylation reaction of CYP4A1 leading to the formation of 20-HETE. Arachidonate metabolism studies using inhibitors such as PPOH may be useful in elucidating the role of metabolites in regulating renal function and hypertension.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov