产品名称

LY255283

一般描述

LY255283 is a competitive leukotriene B4 receptor antagonist, with an IC50 of about 100 nM.

别称

1-(5-Ethyl-2-hydroxy-4-(6-methyl-6-(1H-tetrazol-5-yl)heptyloxy)phenyl)ethanone

纯 度

≥98.0%(HPLC)

CAS NO.

117690-79-6

分子式

C¹⁹H²⁸N⁴O³

分子量

360.45

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

灰白色至浅黄色固体

溶解性(25℃)

DMSO

≥20mg/mL

l  生物学信息

生物活性/药理作用

LY255283 is a competitive leukotriene B4 receptor antagonist, with an IC₅₀ of about 100 nM. It is somewhat selective for the BLT2 receptor, since IC50 values at the BLT1 receptor are >10 μM. LY255283 reduces airway obstruction in animal models of asthma.

应用

LY255283, a competitive leukotriene B4 receptor antagonist, is used in leukotriene receptor research along with other selective leukotriene receptor agonists and antagonist to identify and differentiate the physiological and cell signaling effects of the leukotriene B4 receptor on processes such as paclitaxel resistance in MCF-7/DOX breast cancer cells, monocyte-derived dendritic cell chemotaxis, and 5-lipoxygenase activity and interleukin-8 production in human neutrophils. LY255283 may be used to help verify that an observed process or cell event is leukotriene B4 receptor-dependent.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov