备注:
国外库存,货期2-4周,具体详情请联系销售人员。
详细介绍
l 基本信息 |
产品名称 | AUDA |
一舨描述 | AUDA is a potent inhibitor of soluble epoxide hydrolase. |
别称 | 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 479413-70-2 |
分子式 | C23H40N2O3 | 分子量 | 392.58 |
适用范围 | 生物试剂,适用于细胞培养等 |
l 理化信息 |
外 观 | 白色至米色固体 |
溶解性 | DMSO | ≥10mg/mL(at warmed to 60 °C) |
l 生物学信息 |
生物活性/药理作用 | AUDA is a potent inhibitor of soluble epoxide hydrolase. Inhibition of soluble epoxide hydrolase by AUDA inhibits the metabolism of epoxyeicosatrienoic acids (EETs) and protects end-organs against the damaging effects of salt-sensitive hypertension. AUDA also renders protection against myocardial ischemia reperfusion injury and cerebral ischemia. |
应用 | AUDA has been used in the inhibition of epoxide hydrolase in human macrophages and in inhibition of tumor necrosis factor α (TNF-α)- induced phosphorylation in human aortic smooth muscle cells. |
l 存储 |
存储温度 | -20℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |