产品名称

AUDA

一舨描述

AUDA is a potent inhibitor of soluble epoxide hydrolase.

别称

12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid

纯 度

≥98.0%(HPLC)

CAS NO.

479413-70-2

分子式

C²³H⁴⁰N²O³

分子量

392.58

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至米色固体

溶解性

DMSO

≥10mg/mL(at warmed to 60 °C)

l  生物学信息

生物活性/药理作用

AUDA is a potent inhibitor of soluble epoxide hydrolase.

Inhibition of soluble epoxide hydrolase by AUDA inhibits the metabolism of epoxyeicosatrienoic acids (EETs) and protects end-organs against the damaging effects of salt-sensitive hypertension. AUDA also renders protection against myocardial ischemia reperfusion injury and cerebral ischemia.

应用

AUDA has been used in the inhibition of epoxide hydrolase in human macrophages and in inhibition of tumor necrosis factor α (TNF-α)- induced phosphorylation in human aortic smooth muscle cells.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov