产品名称

15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid

一般描述

Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase.

别 称

 (S)-15-HETE, 15(S)-HETE; (15S,5Z,8Z,11Z,13E)-15-Hydroxyeicosatetraenoic acid

纯 度

≥97.0%(HPLC)

CAS NO.

54845-95-3

分子式

C²⁰H³²O³

分子量

320.47

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

溶液

溶解性(25℃)

DMSO

150 μg/mL

l  生物学信息

生物活性/药理作用

Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov