产品名称

Prostaglandin I2 sodium salt

一般描述

Prostacyclin is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells.

别称

(5Z,9α,11α,13E,15S)-6,9-Epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acid sodium salt, Epoprostenol sodium salt, PGI2-Na, Prostacyclin sodium salt

纯 度

≥96.0%(HPLC)

CAS NO.

61849-14-7

分子式

C²⁰H³¹NaO⁵

分子量

374.45

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至灰白色固体

溶解性(25℃)

乙醇

≥35mg/mL

水

Slightly soluble

l  生物学信息

生物活性/药理作用

Prostacyclin is a short-lived product of the cyclooxygenase pathway in vascular endothelial cells. It is a potent inhibitor of platelet aggregation by antagonizing thromboxane A2 and stimulating platelet adenylyl cyclase.[1] Nitric oxide is also produced in vascular endothelium where it inhibits platelet aggregation, regulates inducible cyclooxygenase production, and may work synergistically with prostacyclin to attenuate the thrombotic process. Prostacyclin is vasoprotective, protecting arterial walls from injury-induced lesions and cytoprotective in the liver and gastrointestinal tract.

Prostacyclin therapy improves hemodynamics in pulmonary arterial hypertension.

应用

Prostaglandin I2 sodium salt has been used:

•   in the preparation of stock solution for platelet washing procedure

•   as supplement in platelet-rich-plasma, for platelet preparation

•   to prevent platelet activation

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov