备注:
国外库存,货期2-4周,具体详情请联系销售人员。
详细介绍
l 基本信息 |
产品名称 | SC 19220 |
一般描述 | SC 19220 is a competitive antagonist of prostaglandin E receptors. |
别称 | 2-Acetylhydrazide 10(11H)-carboxylic acid, 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid |
纯 度 | ≥98.0%(HPLC) | CAS NO. | 19395-87-0 |
分子式 | C16H14N3O3Cl | 分子量 | 331.75 |
适用范围 | 生物试剂,适用于细胞培养等 |
l 理化信息 |
外 观 | 白色固体 |
溶解性(25℃) | DMSO | ≥5mg/mL |
水 | Insoluble |
l 生物学信息 |
生物活性/药理作用 |
EP1 Prostanoid receptor antagonist SC 19220 is a competitive antagonist of prostaglandin E receptors. It competes with PGE2 in regulating vesicourethral motility and increases the bladder capacity of rats. It inhibits the contraction of smooth muscles in response to prostaglandins E2 and F2α.SC 19220 also inhibits the formation of osteoclasts induced by vitamin D3, parathyroid hormone, IL-11 and IL-6. |
应用 | SC 19220 was used to study the role of prostaglandin E2 in oxygen-glucose deprivation induced neurotoxicity and preconditioning-induced neuroprotection in rat cortical cultures. |
l 存储 |
存储温度 | -20℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |