产品名称

COG 133 trifluoroacetate salt

一般描述

COG 1333 or apoE(133-149) is a fragment of Apolipoprotein E (APOE) that mimics the functional anti-inflammatory and neuroprotective effects of the intact apoE protein.

别称

Ac- LRVRLASHLRKLRKRLL-NH2, Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu- Arg-Lys-Leu Arg-Lys-Arg-Leu-Leu-NH2, COG133, N-acetyl-L-leucyl-L-arginyl-L-valyl-L-arginyl-L-leucyl-L-alanyl-L-seryl-L-histidyl-L-leucyl-L-arginyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-arginyl-L-leucyl-L-Leucinamide, apoE(133-149)

纯 度

≥95.0%(HPLC)

CAS NO.

514200-66-9 (free base)

分子式

C⁹⁷H¹⁸¹N³⁷O¹⁹ · xC²HF³O²

分子量

2169.71 (free base basis)

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色固体

溶解性(25℃)

水

Slightly soluble

l  生物学信息

生物活性/药理作用

COG 1333 or apoE(133-149) is a fragment of Apolipoprotein E (APOE) that mimics the functional anti-inflammatory and neuroprotective effects of the intact apoE protein. It was suggested that neuroprotective functions of the mimetic results from binding to the low density lipoprotein receptor-related protein (LRP) or LDL receptors, and such binding results in inhibition of the N-methyl-D-aspartate (NMDA) receptor.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov