产品名称

S-2E

一般描述

HMG-CoA reductase and acetyl-CoA carboxylase inhibitor. In the liver, S-2E is converted into its active metabolite, S-2E-CoA.

别称

(S)-(+)-4-[1-(4-tert-Butylphenyl)-2-oxo-pyrrolidin-4-yl]methoxybenzoic acid

纯 度

≥98.0%(HPLC)

CAS NO.

155730-92-0

分子式

C²²H²⁵NO⁴

分子量

367.44

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色固体

溶解性(25℃)

DMSO

≥5mg/mL

水

insoluble

l  生物学信息

生物活性/药理作用

HMG-CoA reductase and acetyl-CoA  carboxylase inhibitor. In the liver, S-2E is converted into its active metabolite, S-2E-CoA. S-2E-CoA noncompetitively inhibited the enzymatic   activities of both 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase and acetyl-CoA carboxylase at K(i)=18.11 microM and K(i)=69.2 microM, respectively.

应用

S-2E may be used in cell signaling studies.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov