产品名称

T863

一般描述

T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells.

别称

2-((1,4-trans)-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-   phenyl)cyclohexyl)acetic acid, T-863, trans-4-[4-(4-Amino-7,7-dimethyl-7H-

纯 度

≥98.0%(HPLC)

CAS NO.

701232-20-4

分子式

C²²H²⁶N⁴O³

分子量

394.47

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至米色固体

溶解性(25℃)

DMSO

≥5mg/mL

l  生物学信息

生物活性/药理作用

T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice.

应用

T863 has been used as a diglyceride acyltransferase (DGAT1) inhibitor:

•   to provide the opportunity to precisely control the DGAT inhibition

•   to treat mouse embryonic fibroblasts (MEFs) to analyse lipid droplet biogenesis

•   to specifically block neutral lipid synthesis and lipid droplet formation in HT-1080 cells

•   to block lipid droplet (LD) formation

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov