产品名称

Triacsin C from Streptomyces sp.

一般描述

Triacsin C is a potent inhibitor of long-chain fatty acyl CoA synthetase.

别 称

WS1228A; 2,4,7-Undecatrienal nitrosohydrazone

纯 度

≥95.0%(HPLC)

CAS NO.

76896-80-5

分子式

C¹¹H¹⁷N³O

分子量

207.27

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

灰白色至淡黄色固体

l  生物学信息

生物活性/药理作用

Triacsin C is a potent inhibitor of long-chain fatty acyl CoA synthetase. It blocks β-cell apoptosis, induced by fatty acids (lipoapoptosis) in a rat model of obesity. In addition, it blocks the de novo synthesis of triglycerides, diglycerides, and cholesterol esters, thus interfering with lipid metabolism.

应用

Triacsin C was found to induce maturation in mouse and Xenopus oocytes in the absence of long-chain acyl-CoA synthetase. Triacsin C can also block palmitoylation of the G-protein alpha S subunit6. Furthermore, triacsin C can stabilize1-oleoyl-2-acetyl-sn-glycerol (OAG) and enhance perilipin 3 recruitment to the endoplasmic reticulum (ER) in mouse cells7.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov