产品名称

Zaragozic acid A trisodium salt

一般描述

Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces   cervisiaesqualene synthase.

别 称

L-694,599;Squalestatin

纯 度

≥95.0%(HPLC)

CAS NO.

144541-82-2

分子式

C³⁵H⁴³O¹⁴Na³

分子量

756.68

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至淡黄色/棕褐色冻干粉

溶解性(25℃)

DMSO

≥5 mg/mL

l  生物学信息

生物活性/药理作用

Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiaesqualene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.

应用

Zaragozic acid A trisodium salt has been used as:

•  a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing

•   a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells

•  a cholesterol synthesis inhibitor in T cells

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov