产品名称

LY-294,002 hydrochloride

一般描述

LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K).

别称

2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride

纯 度

≥98.0%(HPLC)

CAS NO.

934389-88-5

分子式

C¹⁹H¹⁷NO³ · HCl

分子量

343.8

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至灰白色固体

溶解性(25℃)

DMSO

≥5mg/mL

水

Insoluble

l  生物学信息

生物活性/药理作用

Specific cell permeable phosphatidylinositol 3-kinase inhibitor. LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.

应用

LY-294,002 hydrochloride has been used in the inhibition of:

•   phosphoinositide 3-kinase (PI3K) in human lung cancer cell line

•   autophagy in mesenchymal stem cells (MSCs).

•   serine/threonine-specific protein kinase (AKT) signaling in fibroblasts and cardiac cells.

l  存储

存储温度

-20℃

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov