Novel, selective human sphingosine-1-phosphate subtype 1 (S1P1) receptor agonist. SEW2871 is a selective agonist of spingosine-1 phosphate receptor. It exacerbates reperfusion arrhythmias by significantly prolonging the duration of ventricular tachycardia and ventricular fibrillation.SEW2871 modulates inflammatory reactions by influencing lymphocyte homing and cell migration.By the inhibition of proinflammatory molecules, SEW2871 reduces acute renal failure due to ischemia. |