备注:
国外库存,货期2-4周,具体详情请联系销售人员。
详细介绍
l 基本信息 |
产品名称 | THI |
一般描述 | THI is an inhibitor of sphingosine-1-phosphate lyase and acts as an immunosuppressant. |
别称 | 2-Acetyl-4-tetrahydroxybutyl Imidazole; 1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl]-ethanone, 2-ATHBI |
CAS NO. | 94944-70-4 |
分子式 | C9H14N2O5 | 分子量 | 230.22 |
适用范围 | 生物试剂,适用于细胞培养等 |
l 理化信息 |
外 观 | 白色至浅棕色固体 |
溶解性(25℃) | DMSO | Slightly soluble |
l 生物学信息 |
生物活性/药理作用 | 2-Acetyl-4-tetrahydroxybutyl imidazole (THI) is known to induce peripheral blood lymphopenia in rats. Studies in rats have also reported that THI can affect lymphocyte migration and degradation. THI is an inhibitor of sphingosine-1-phosphate lyase and acts as an immunosuppressant. Sphingosine-1-phosphate (S1P) lyase catalyzes the irreversible decomposition of S1P to hexadecanaldehyde and phosphoethanolamine. Reducing S1P lyase activity results in therapeutic levels of immunosuppression without the non-lymphoid lesions that result from synthetic S1P receptor agonists. |
l 存储 |
存储温度 | -20℃ |
l 注意事项及免责声明 |
本产品仅用于实验研究,不得作为药物使用,不得用于家用或其它用途。 |
l 参考文献 |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |