产品名称

Violacein from Janthinobacterium lividum

一般描述

Violacein, a violet pigment, is an indole derivative.

纯 度

>98% (violacein (minimum 85% violacein) and deoxyviolacein, HPLC)

CAS NO.

548-54-9

分子式

C²⁰H¹³N³O³

分子量

343.34

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

深蓝色至极深蓝色，紫色至极紫色，蓝紫色和紫蓝色粉末

l  生物学信息

生物活性/药理作用

Violacein, a violet pigment, is an indole derivative produced by various bacterial strains such as Chromobacterium violaceum, Janthinobacterium lividum, Chromobacterium lividum, and Pseudoalteromonas luteoviolacea. Violacein is a member of a novel class of cytotoxic drugs, which mediate apoptosis. Violacein exhibits antitumoral, antibacterial, antiulcerogenic, antileishmanial, and antiviral activities. Violacein and its β-cyclodextrin complexes trigger apoptosis and differentiation in HL60 leukemic cells. Violacein cytotoxicity is preceded by activation of caspase 8, tranion of NF-κB target genes, and p38-MAPK activation resembling TNF-α signal transduction.

l  存储

存储温度

2-8°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov