产品名称

Arachidonic acid sodium salt from Mortierella alpine(来自高山被孢霉的花生四烯酸钠盐)

一般描述

Arachidonic acid (AA) is a polyunsaturated ϖ fatty acid constituent of the phospholipids of cell membranes.

别 称

5,8,11,14-Eicosatetraenoic acid, Eicosa-5Z,8Z,11Z,14Z-tetraenoic acid, Sodium arachidonate, cis,cis,cis,cis-5,8,11,14-Eicosatetraenoic acid sodium salt, 20:4

纯 度

≥98.5%(GC)

CAS NO.

6610-25-9

分子式

C²⁰H³¹O²Na

分子量

326.45

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至白色蜡状固体

溶解性(25°C)

乙醇

≥25mg/mL

l  生物学信息

生物活性/药理作用

Released arachidonic acid (AA) reacts with molecular oxygen nonenzymatically, through oxidative stress, and enzymatically through the action of oxygenase enzymes. AA is oxidized to prostaglandins and thromboxanes by at least two cyclooxygenase (COX) isoforms, to leukotrienes and lipoxins by lipoxygenases, and to epoxyeicosatrienoic acids via cytochrome p450-catalyzed metabolism. Cellular uptake of arachidonic acid is energy dependent and involves protein-facilitated transport across the plasma membrane.

应 用

Arachidonic acid is used in assays to measure activity of oxidizing enzymes, such as cyclooxygenase, as well as in assays to determine platelet inhibition in whole blood. Arachidonic acid has been demonstrated to bind to the a subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs), to have a role in the development and progression of prostate cancer, and to enhance formation of lipid bodies in human mast cells.

l  存储

存储温度

−20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov