产品名称

Globomycin from Streptomyces hagronensis

一般描述

Globomycin is a cyclic peptide antibiotic, which inhibits the growth of enteric Gram-negative bacteria through cell wall synthesis inhibition.

别 称

Glycine, N-(N-(N-(N-(N-(3-hydroxy-2-methyl-1-oxononyl)-N-methylleucyl)-L-alloisoleucyl)-L-seryl)-L-allothreonyl)-, rho-lactone, SF1902

纯 度

≥98%(HPLC)

CAS NO.

67076-74-8

分子式

C³²H⁵⁷N⁵O⁹

分子量

655.82

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色粉末

溶解性(25°C)

DMSO

~1mg/mL

l  生物学信息

生物活性/药理作用

Globomycin was found to inhibit LspA, a lipoprotein signal peptidase. It eliminates the maturation of pro-lipoproteins by inhibition of the enzyme that converts pro-lipoprotein to lipoprotein, acting as a substrate analog of the signal sequence in the outer membrane of Gram-negative bacteria.

l  存储

存储温度

−20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov