产品名称

Cyclopiazonic acid from Penicillium  cyclopium(环盐酸吗甲吡嗪酸 来源于圆弧青霉菌)

一般描述

Cyclopiazonic acid (CPA), a tetramic acid  is synthesized by various Aspergillus and Penicillium species.

别 称

CPA

纯 度

≥98%(HPLC)

CAS NO.

18172-33-3

分子式

C₂₀H₂₀N₂O₃

分子量

336.38

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

白色至白色带黄色粉末

溶解性(25°C)

DMSO

soluble

l  生物学信息

生物活性/药理作用

Inhibits the sarcoplasmic reticulum Ca₂₊-pump.

应 用

Cyclopiazonic acid from Penicillium cyclopium has been used:

•  as a standard in aflatoxin detection and quantification by thin layer chromatography (TLC)

•  as a component in Ca2+-free DMEM/10% fetal bovine serum (FBS)

•  as a reversible inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) to examine the role of luminal calcium in endoplasmic recticulum (ER)-to-Golgi trafficking

•  as an endoplasmic reticulum Ca2+-ATPase blocker, to treat neurons and also to study the role of the endoplasmic reticulum (ER) in releasing and sustaining Ca2+ during Ca2+-induced Ca2+ release (CICR) to inhibit SERCA

l  存储

存储温度

−20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov