产品名称

Okadaic acid from Prorocentrum concavum(豆渣酸来源于凹形原甲藻)

一般描述

Okadaic acid is a polyether fatty acid. It is a marine toxin produced by the genera of Prorocentrum and Dinophysis.

别 称

OA

含 量

92-100%(HPLC)

CAS NO.

78111-17-8

分子式

C⁴⁴H⁶⁸O¹³

分子量

805

适用范围

生物试剂，适用于细胞培养等

l  理化信息

溶解性(25°C)

DMSO

≥1 mg/mL

乙醇

≥1 mg/mL

水

insoluble

l  生物学信息

生物活性/药理作用

Dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. Readily enters cells. Inhibitor of type 1 and type 2A protein phosphatases. Does not inhibit tyrosine phosphatases, alkaline phosphatases or acid phosphatase. Known tumor promotor. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling.

应 用

Okadaic acid from Prorocentrum concavum has been used as a phosphatase inhibitor:

•  to inhibit protein phosphatase 2 in spermatocytes culture

•  to treat SH-SY5Y cells to prevent dephosphorylation to maintain tau

•  to treat human embryonic kidney 293T cells (HEK293T) or H4 cells to analyse its effect on fused in sarcoma (FUS) protein

l  存储

存储温度

−20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov