产品名称

Fostriecin sodium salt from Streptomyces pulveraceus

一般描述

Fostriecin sodium salt is an antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM).

别 称

FOSTRIECIN SODIUM

纯 度

≥98%(HPLC)

CAS NO.

87860-39-7

分子式

C¹⁹H²⁶NaO⁹P

分子量

452.37

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

固体

l  生物学信息

生物活性/药理作用

An antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM). Inhibits protein phosphatase 1 (PP1) at much higher concentrations (IC₅₀ = 131 µM). Does not affect the activity of protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G2/M phase of the cell cycle in a dose-dependent manner.

l  存储

存储温度

−20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov