产品名称

Pyocyanin(绿脓菌素) from Pseudomonas aeruginosa

一般描述

Pyocyanin, a blue-green pigment belonging to phenazine pigments, is a redox-active phenazine.

别 称

5-Methyl-1(5H)-phenazinone, Pyocyanine, Sanasin, Sanazin

纯 度

≥98%(HPLC)

CAS NO.

85-66-5

分子式

C¹³H¹⁰N²O

分子量

210.23

适用范围

生物试剂，适用于细胞培养等

l  理化信息

外 观

蓝色粉末或固体

溶解性(25°C)

DMSO

soluble

乙醇

soluble

l  生物学信息

生物活性/药理作用

Pyocyanin, a blue-green pigment belonging to phenazine pigments, is a redox-active phenazine. Pyocyanin is an electron receptor, which stimulates redox cycling in bacteria, liver cells, and human epithlial cell lines. Pyocyanin enhances the oxidative metabolism, which in turn increases the formation of intracellular reactive oxygen species (ROS) via reduction of NADPH. Pyocyanin also increases the release of IL-8 by airway epithelial cells both in vitro and in vivo. This involves signal transduction pathways that include oxidants, protein tyrosine kinases, and MAP kinases. IL-8 secretion by these cells is in synergy with inflammatory cytokines. Pyocyanin has been shown to accelerate neutrophil apoptosis in vitro, resulting in resolution of acute inflammation, which is beneficial for bacteria survival.

l  存储

存储温度

−20°C

l  注意事项及免责声明

本产品仅用于实验研究，不得作为药物使用，不得用于家用或其它用途。

l  参考文献

1.    http://www.drugbank.ca

2.    https://ncit.nci.nih.gov

3.  https://www.ncbi.nlm.nih.gov